Exercise Physiology
Fariba Pourasghar; jabbar bashiri; Roghayeh Pouzesh Jadidi; HASSAN POURRAZI; Mir Alireza Nourazar
Abstract
Aim: The aim of the present study is to investigate the effect of intense interval exercise training and melatonin supplementation on the apoptotic indices of kidney tissue in rats suffering from renal ischemia reperfusion injury. Methods: 30 male Wistar rats (weight: 250 and 300 grams) were randomly ...
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Aim: The aim of the present study is to investigate the effect of intense interval exercise training and melatonin supplementation on the apoptotic indices of kidney tissue in rats suffering from renal ischemia reperfusion injury. Methods: 30 male Wistar rats (weight: 250 and 300 grams) were randomly divided into 5 groups, healthy, Ischemia/Reperfusion (I/R), I/R + intense interval training, I/R + melatonin supplement and I/R + high intensive interval training + melatonin supplement. Except for the healthy group, the animals were subjected to ischemia-reperfusion in other test groups. The high intensive interval training protocol was implemented for 12 weeks (5 days per week). Caspase 3, BAX, BCL2 and TNFα gene expression indices were measured by real time PCR method. Because of the non-normal distribution of parameters, the data were analysed by Kruskal–Wallis, Mann–Whitney and Wilcoxon test at the significance level of p
Exercise Physiology
Mehdi Pahlevani; Jabbar Bashiri; Roghayeh Pouzesh Jadidi; Rasoul Hashem Kandi Asadi; Masoomeh Dadkhah
Abstract
Exercise and supplementation prevent the dysfunction of BDNFand disorder in the serum levels ofCRPandIL-6caused by diabetes.The purpose of the study wasto determine the simultaneous effect of2months of combined training and taurine supplementation onBDNF,CRPandIL-6indices in diabetic rats.In this experimental ...
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Exercise and supplementation prevent the dysfunction of BDNFand disorder in the serum levels ofCRPandIL-6caused by diabetes.The purpose of the study wasto determine the simultaneous effect of2months of combined training and taurine supplementation onBDNF,CRPandIL-6indices in diabetic rats.In this experimental study.30 adult male Wistar rats(250-300 grams and aged six weeks)were randomly divided into three groups diabetic exercisesupplementation(n=10),diabetic control(n=10)and healthy control(n=10).At the end of the8weekold,the amount of 55 mg/kg of body weight of streptozocin(STZ)was injected intraperitoneally,to make diabetic.The diabetic exercise-supplementation group performed the two months of combined exercises,5timesperweek(aerobic exercise with75%Vo2max on the treadmill and strength training includes15 times climbing the ladder).Taurine supplement was available to rats in the form ofa1%solution in daily drinking water(500 ml).The serum levels of BDNF,CRP and IL-6 were measured with Eliza method.OnewayANOVAand posthoc Tukey test were used to compare betweengroup and intragroup changes of BDNF,CRP,IL-6.The significance levelwasP<0.05.After two months of aerobicstrength training and taurine supplementation,BDNFserum level significantly increased in the diabetic exercise group compare to the diabetic group(P=0.003).Whereas,it significantly decreased in the diabetic control group compared to the healthy control(P=0.0001).CRPserumlevel significantly decreased in the diabetic exercise-supplementation group compare to the diabetic group(P=0.008).Whereas, it significantly increased the diabetic controlgroup compared to the healthy control(P=0.0001).After2months of aerobicstrength training and taurine supplementation there was no significant change inIL-6 serum level in the diabetic exercisesupplement group compared tothe diabetic control group andinthe diabetic control group compare to the healthy control(P=0.059).According to the findings ofthis research,2months of simultaneous aerobic-strength training and taurine supplementation are recommended to increaseBDNFlevels and reduce inflammationin diabetics.
Exercise Physiology
nooshin salehi aghdam; Roghayeh Pouzesh Jadidi; Karim Azali Alamdari; jabbar bashiri; Mir Ali Reza Nourazar
Abstract
Aim: we investigated the effects of six weeks of HIIT and curcumin supplementation on hepatic cellular death and also GSH level in male rats exposed to drinking water arsenic.Methods: 48 rats were randomized in six groups including HIIT, curcumin, HIIT+curcumin, arsenic, ethanol control and normal control. ...
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Aim: we investigated the effects of six weeks of HIIT and curcumin supplementation on hepatic cellular death and also GSH level in male rats exposed to drinking water arsenic.Methods: 48 rats were randomized in six groups including HIIT, curcumin, HIIT+curcumin, arsenic, ethanol control and normal control. Arsenic 5 mg/bw.day and curcumin 15 mg/bw.day, were consumed orally for entire the study period. HIIT were conducted for six weeks (5 d/w, 60 min/session (with 4 min running at 85-90% of Vo2max and 2 min recovery at 50-60% of Vo2max intervals). Results: Arsenic exposure down regulated hepatic CK18 M65 level and also in a lesser extent; the cellular GSH content. Curcumin supplementation either alone or concomitantly with HIIT, could reverse the changes in hepatic CK18 M65 level. However; only in the HIIT+curcumin group, a remarkable elevation of hepatic GSH level was observed. Conclusion: Arsenic exposure renders liver to an increased oxidative stress and apoptosis level and the both HIIT and curcumin supplementation have appreciable effects to neutralize these hazardous effects. Moreover, only the synergistic effect of HIIT and curcumin supplementation could attenuate the liver antioxidants following arsenic exposure. However, more investigations remains to be done because of the study limitations and lack of similar evidence in this area.
